Outcomes in COVID-19 molnupiravir studies
Outcomes in molnupiravir studies.
Potential risks include the creation of dangerous variants, and mutagenicity, carcinogenicity, teratogenicity, and embryotoxicity Chamod , Gruber , Hadj Hassine , Huntsman , Marikawa , Shiraki , Shum , Standing , Swanstrom , Waters , Zhou , Zibat Multiple analyses have identified variants potentially created by molnupiravir
Fountain-Jones , Kosakovsky Pond , Sanderson , twitter.com . There is substantial publication bias. Multiple trials have not reported results and did not respond to requests
Lawrence .
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1.5+ All studies 11% 46 151,398 Improvement, Studies, Patients Relative Risk Mortality 15% 24 124,940 Ventilation 20% 8 24,515 ICU admission 6% 7 28,430 Hospitalization 2% 20 79,514 Progression 32% 6 33,432 Recovery 12% 11 28,091 Cases 24% 1 1,527 Viral clearance 25% 13 9,337 RCTs 23% 17 31,458 RCT mortality -1% 5 25,832 Peer-reviewed 14% 34 122,324 Prophylaxis 24% 1 1,527 Early 12% 36 94,682 Late 11% 9 55,189 Molnupiravir for COVID-19 c19 earlyOctober 2024 after exclusions Favors molnupiravir Favors control
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2+ Fischer (RCT) 77% 0.23 [0.01-5.69] death 0/140 1/62 Improvement, RR [CI] Treatment Control Hetero (RCT) 70% 0.30 [0.13-0.70] hosp. 7/371 23/370 Optimus (RCT) 58% 0.42 [0.31-0.58] viral+ 38/175 93/180 Khoo (RCT) -33% 1.33 [0.55-3.26] no recov. 8/12 3/6 MOVe-OUT Jayk Ber.. (DB RCT) 89% 0.11 [0.01-0.86] death 1/709 9/699 Tippabhotla (RCT) 46% 0.54 [0.22-1.34] hosp. 7/610 13/610 Wong (PSM) 52% 0.48 [0.40-0.59] death 1,856 (n) 1,856 (n) Yip (PSW) -12% 1.12 [0.68-1.82] death/ICU Zou (RCT) 29% 0.71 [0.28-1.85] recov. time 77 (n) 31 (n) Flisiak 39% 0.61 [0.38-0.97] death 20/203 63/387 AGILE CST-2 Khoo (DB RCT) 67% 0.33 [0.01-8.08] oxygen 0/90 1/90 Kneidinger -15% 1.15 [0.56-2.37] severe case 8/46 26/172 Najjar-Deb.. (PSM) 19% 0.81 [0.46-1.43] death 22/2,661 27/2,661 Arbel 65+ 74% 0.26 [0.10-0.73] death 4/845 137/12,724 Arbel 40-64 -1182% 12.82 [3.41-48.2] death 4/224 7/6,075 Suzuki (PSM) -100% 2.00 [0.34-11.9] death 2/230 3/690 Brown -101% 2.01 [0.43-9.38] hosp. 8/442 2/222 PANORAMIC Butler (RCT) -27% 1.27 [0.65-2.48] death 20/11,778 15/11,230 Wong (PSM) 24% 0.76 [0.61-0.95] death Liu -162% 2.62 [0.11-60.6] ICU 1/26 0/16 Sinha (RCT) 65% 0.35 [0.16-0.73] hosp. 9/608 26/610 Zheng -100% 2.00 [1.23-3.23] death/hosp. 61/2,689 34/3,331 OT1 Bajema (PSM) 18% 0.82 [0.52-1.29] death 24/897 29.0/897 Inaba 58% 0.42 [0.02-10.1] death 0/84 1/210 Zheng (PSW) -285% 3.85 [1.54-10.0] death/hosp. 11/802 33/4,836 OT1 Evans 51% 0.49 [0.29-0.83] death/hosp. 359 (n) 4,973 (n) Goodwin -110% 2.10 [0.19-22.9] death 1/80 2/336 Tazare -9% 1.09 [0.93-1.27] death/hosp. Butt -9% 1.09 [0.73-1.63] death/hosp. 48/1,459 44/1,459 Fung 4% 0.96 [0.93-0.99] PASC population-based cohort LONG COVID DAWN Tare (RCT) -83% 1.83 [0.69-4.82] no recov. 4/7 5/16 Cheng 15% 0.85 [0.77-0.95] death 4,146 (n) 5,792 (n) Standing (RCT) -103% 2.03 [0.52-7.94] viral+ 6/117 3/119 Razia -272% 3.72 [0.35-39.4] death 2/29 1/54 Yen 18% 0.82 [0.50-1.33] death 250 (n) 1,946 (n) SAVALO Gentile (PSM) 4% 0.96 [0.70-1.31] death case control Tau2 = 0.08, I2 = 80.5%, p = 0.072 Early treatment 12% 0.88 [0.76-1.01] 316/32,022 601.0/62,660 12% lower risk 033864 (RCT) 0% 1.00 [0.50-2.00] improv. n/a n/a FUTILITY, PENDING2 Improvement, RR [CI] Treatment Control 035424 (RCT) 0% 1.00 [0.50-2.00] improv. n/a n/a FUTILITY, PENDING2 MOVe-IN Arribas (DB RCT) -282% 3.82 [0.50-29.1] death 11/216 1/75 Wan 11% 0.89 [0.81-0.98] death 704/6,153 2,541/17,283 Wan 13% 0.87 [0.81-0.93] death 2,700 (n) 13,795 (n) Özdemir -50% 1.50 [0.27-8.49] death 3/39 2/39 RECOVERY Horby (RCT) -11% 1.11 [0.79-1.58] death 57/445 55/478 Lv -53% 1.53 [0.83-2.83] death 12/67 30/257 Lai 10% 0.90 [0.83-0.97] death 4,975 (n) 8,667 (n) Tau2 = 0.00, I2 = 0.0%, p < 0.0001 Late treatment 11% 0.89 [0.85-0.93] 787/14,595 2,629/40,594 11% lower risk MOVe-AHEAD Alpizar (DB RCT) 24% 0.76 [0.57-1.01] symp. case 78/763 103/764 Improvement, RR [CI] Treatment Control Tau2 = 0.00, I2 = 0.0%, p = 0.049 Prophylaxis 24% 0.76 [0.57-1.01] 78/763 103/764 24% lower risk All studies 11% 0.89 [0.81-0.97] 1,181/47,380 3,333.0/104,018 11% lower risk 46 molnupiravir COVID-19 studies c19 earlyOctober 2024 Tau2 = 0.03, I2 = 76.8%, p = 0.0068 Effect extraction pre-specified 1 OT: comparison with other treatment 2 FUTILITY: terminated for futility, results pending Favors molnupiravir Favors control
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2+ Fischer (RCT) 77% 0.23 [0.01-5.69] death 0/140 1/62 Improvement, RR [CI] Treatment Control Hetero (RCT) 70% 0.30 [0.13-0.70] hosp. 7/371 23/370 Optimus (RCT) 58% 0.42 [0.31-0.58] viral+ 38/175 93/180 Khoo (RCT) -33% 1.33 [0.55-3.26] no recov. 8/12 3/6 MOVe-OUT Jayk Ber.. (DB RCT) 89% 0.11 [0.01-0.86] death 1/709 9/699 Tippabhotla (RCT) 46% 0.54 [0.22-1.34] hosp. 7/610 13/610 Wong (PSM) 52% 0.48 [0.40-0.59] death 1,856 (n) 1,856 (n) Yip (PSW) -12% 1.12 [0.68-1.82] death/ICU Zou (RCT) 29% 0.71 [0.28-1.85] recov. time 77 (n) 31 (n) Flisiak 39% 0.61 [0.38-0.97] death 20/203 63/387 AGILE CST-2 Khoo (DB RCT) 67% 0.33 [0.01-8.08] oxygen 0/90 1/90 Kneidinger -15% 1.15 [0.56-2.37] severe case 8/46 26/172 Najjar-Deb.. (PSM) 19% 0.81 [0.46-1.43] death 22/2,661 27/2,661 Arbel 65+ 74% 0.26 [0.10-0.73] death 4/845 137/12,724 Arbel 40-64 -1182% 12.82 [3.41-48.2] death 4/224 7/6,075 Suzuki (PSM) -100% 2.00 [0.34-11.9] death 2/230 3/690 PANORAMIC Butler (RCT) -27% 1.27 [0.65-2.48] death 20/11,778 15/11,230 Wong (PSM) 24% 0.76 [0.61-0.95] death Liu -162% 2.62 [0.11-60.6] ICU 1/26 0/16 Sinha (RCT) 65% 0.35 [0.16-0.73] hosp. 9/608 26/610 Zheng -100% 2.00 [1.23-3.23] death/hosp. 61/2,689 34/3,331 OT1 Bajema (PSM) 18% 0.82 [0.52-1.29] death 24/897 29.0/897 Inaba 58% 0.42 [0.02-10.1] death 0/84 1/210 Evans 51% 0.49 [0.29-0.83] death/hosp. 359 (n) 4,973 (n) Goodwin -110% 2.10 [0.19-22.9] death 1/80 2/336 Tazare -9% 1.09 [0.93-1.27] death/hosp. Butt -9% 1.09 [0.73-1.63] death/hosp. 48/1,459 44/1,459 Fung 4% 0.96 [0.93-0.99] PASC population-based cohort LONG COVID DAWN Tare (RCT) -83% 1.83 [0.69-4.82] no recov. 4/7 5/16 Cheng 15% 0.85 [0.77-0.95] death 4,146 (n) 5,792 (n) Standing (RCT) -103% 2.03 [0.52-7.94] viral+ 6/117 3/119 Razia -272% 3.72 [0.35-39.4] death 2/29 1/54 Yen 18% 0.82 [0.50-1.33] death 250 (n) 1,946 (n) SAVALO Gentile (PSM) 4% 0.96 [0.70-1.31] death case control Tau2 = 0.07, I2 = 79.6%, p = 0.012 Early treatment 16% 0.84 [0.73-0.96] 297/30,778 566.0/57,602 16% lower risk 033864 (RCT) 0% 1.00 [0.50-2.00] improv. n/a n/a FUTILITY, PENDING2 Improvement, RR [CI] Treatment Control 035424 (RCT) 0% 1.00 [0.50-2.00] improv. n/a n/a FUTILITY, PENDING2 MOVe-IN Arribas (DB RCT) -282% 3.82 [0.50-29.1] death 11/216 1/75 Wan 11% 0.89 [0.81-0.98] death 704/6,153 2,541/17,283 Wan 13% 0.87 [0.81-0.93] death 2,700 (n) 13,795 (n) Özdemir -50% 1.50 [0.27-8.49] death 3/39 2/39 RECOVERY Horby (RCT) -11% 1.11 [0.79-1.58] death 57/445 55/478 Lv -53% 1.53 [0.83-2.83] death 12/67 30/257 Lai 10% 0.90 [0.83-0.97] death 4,975 (n) 8,667 (n) Tau2 = 0.00, I2 = 0.0%, p < 0.0001 Late treatment 11% 0.89 [0.85-0.93] 787/14,595 2,629/40,594 11% lower risk MOVe-AHEAD Alpizar (DB RCT) 24% 0.76 [0.57-1.01] symp. case 78/763 103/764 Improvement, RR [CI] Treatment Control Tau2 = 0.00, I2 = 0.0%, p = 0.049 Prophylaxis 24% 0.76 [0.57-1.01] 78/763 103/764 24% lower risk All studies 14% 0.86 [0.79-0.94] 1,162/46,136 3,298.0/98,960 14% lower risk 44 molnupiravir COVID-19 studies after exclusions c19 earlyOctober 2024 Tau2 = 0.03, I2 = 75.6%, p = 0.00098 Effect extraction pre-specified 1 OT: comparison with other treatment 2 FUTILITY: terminated for futility, results pending Favors molnupiravir Favors control
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2+ Fischer (RCT) 77% 0.23 [0.01-5.69] 0/140 1/62 Improvement, RR [CI] Treatment Control MOVe-OUT Jayk Ber.. (DB RCT) 89% 0.11 [0.01-0.86] 1/709 9/699 Wong (PSM) 52% 0.48 [0.40-0.59] 1,856 (n) 1,856 (n) Flisiak 39% 0.61 [0.38-0.97] 20/203 63/387 Najjar-Deb.. (PSM) 19% 0.81 [0.46-1.43] 22/2,661 27/2,661 Arbel 65+ 74% 0.26 [0.10-0.73] 4/845 137/12,724 Arbel 40-64 -1182% 12.82 [3.41-48.2] 4/224 7/6,075 Suzuki (PSM) -100% 2.00 [0.34-11.9] 2/230 3/690 PANORAMIC Butler (RCT) -27% 1.27 [0.65-2.48] 20/11,778 15/11,230 Wong (PSM) 24% 0.76 [0.61-0.95] Bajema (PSM) 18% 0.82 [0.52-1.29] 24/897 29.0/897 Inaba 58% 0.42 [0.02-10.1] 0/84 1/210 Goodwin -110% 2.10 [0.19-22.9] 1/80 2/336 Cheng 15% 0.85 [0.77-0.95] 4,146 (n) 5,792 (n) Razia -272% 3.72 [0.35-39.4] 2/29 1/54 Yen 18% 0.82 [0.50-1.33] 250 (n) 1,946 (n) SAVALO Gentile (PSM) 4% 0.96 [0.70-1.31] case control Tau2 = 0.11, I2 = 75.2%, p = 0.08 Early treatment 19% 0.81 [0.64-1.03] 100/24,132 295.0/45,619 19% lower risk MOVe-IN Arribas (DB RCT) -282% 3.82 [0.50-29.1] 11/216 1/75 Improvement, RR [CI] Treatment Control Wan 11% 0.89 [0.81-0.98] 704/6,153 2,541/17,283 Wan 13% 0.87 [0.81-0.93] 2,700 (n) 13,795 (n) Özdemir -50% 1.50 [0.27-8.49] 3/39 2/39 RECOVERY Horby (RCT) -11% 1.11 [0.79-1.58] 57/445 55/478 Lv -53% 1.53 [0.83-2.83] 12/67 30/257 Lai 10% 0.90 [0.83-0.97] 4,975 (n) 8,667 (n) Tau2 = 0.00, I2 = 18.8%, p < 0.0001 Late treatment 11% 0.89 [0.85-0.95] 787/14,595 2,629/40,594 11% lower risk All studies 15% 0.85 [0.76-0.95] 887/38,727 2,924.0/86,213 15% lower risk 24 molnupiravir COVID-19 mortality results c19 earlyOctober 2024 Tau2 = 0.03, I2 = 71.8%, p = 0.0049 Favors molnupiravir Favors control
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2+ Wong (PSM) 58% 0.42 [0.17-1.01] 1,856 (n) 1,856 (n) Improvement, RR [CI] Treatment Control Flisiak 5% 0.95 [0.39-2.32] 7/203 14/387 Suzuki (PSM) 57% 0.43 [0.02-10.5] 0/230 1/690 Wong (PSM) 60% 0.40 [0.19-0.84] Bajema (PSM) 17% 0.83 [0.17-4.12] 3/897 3.6/897 Razia -86% 1.86 [0.12-28.7] 1/29 1/54 Tau2 = 0.00, I2 = 0.0%, p = 0.011 Early treatment 44% 0.56 [0.36-0.88] 11/3,215 19.6/3,884 44% lower risk Wan -7% 1.07 [0.89-1.30] 2,700 (n) 13,795 (n) Improvement, RR [CI] Treatment Control RECOVERY Horby (RCT) -43% 1.43 [0.50-4.08] 8/445 6/476 Tau2 = 0.00, I2 = 0.0%, p = 0.43 Late treatment -8% 1.08 [0.90-1.30] 8/3,145 6/14,271 8% higher risk All studies 20% 0.80 [0.54-1.19] 19/6,360 25.6/18,155 20% lower risk 8 molnupiravir COVID-19 mechanical ventilation results c19 earlyOctober 2024 Tau2 = 0.10, I2 = 35.4%, p = 0.27 Favors molnupiravir Favors control
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2+ Wong (PSM) 26% 0.74 [0.45-1.21] Improvement, RR [CI] Treatment Control Liu -162% 2.62 [0.11-60.6] 1/26 0/16 Bajema (PSM) 1% 0.99 [0.41-2.37] 10/897 10.1/897 Cheng 12% 0.88 [0.59-1.30] 4,146 (n) 5,792 (n) Razia -86% 1.86 [0.28-12.5] 2/29 2/54 Tau2 = 0.00, I2 = 0.0%, p = 0.31 Early treatment 14% 0.86 [0.65-1.15] 13/5,098 12.1/6,759 14% lower risk Wan -2% 1.02 [0.76-1.36] 2,700 (n) 13,795 (n) Improvement, RR [CI] Treatment Control Özdemir 0% 1.00 [0.15-6.75] 2/39 2/39 Tau2 = 0.00, I2 = 0.0%, p = 0.9 Late treatment -2% 1.02 [0.76-1.36] 2/2,739 2/13,834 2% higher risk All studies 6% 0.94 [0.76-1.15] 15/7,837 14.1/20,593 6% lower risk 7 molnupiravir COVID-19 ICU results c19 earlyOctober 2024 Tau2 = 0.00, I2 = 0.0%, p = 0.54 Favors molnupiravir Favors control
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2+ Fischer (RCT) -33% 1.33 [0.14-12.5] hosp. 3/140 1/62 Improvement, RR [CI] Treatment Control Hetero (RCT) 70% 0.30 [0.13-0.70] hosp. 7/371 23/370 Tippabhotla (RCT) 46% 0.54 [0.22-1.34] hosp. 7/610 13/610 Wong (PSM) 6% 0.94 [0.89-1.00] hosp. time 1,856 (n) 1,856 (n) Yip (PSW) -17% 1.17 [0.99-1.39] hosp. Flisiak -1% 1.01 [0.71-1.43] hosp. time 203 (n) 387 (n) AGILE CST-2 Khoo (DB RCT) 89% 0.11 [0.01-2.03] hosp. 0/90 4/90 Arbel 65+ 45% 0.55 [0.34-0.88] hosp. 18/845 513/12,724 Arbel 40-64 -80% 1.80 [0.86-3.77] hosp. 8/224 97/6,075 Brown -101% 2.01 [0.43-9.38] hosp. 8/442 2/222 PANORAMIC Butler (RCT) -7% 1.07 [0.81-1.41] hosp. 103/12,529 96/12,525 Wong (PSM) 2% 0.98 [0.89-1.06] hosp. Liu 18% 0.82 [0.63-1.06] hosp. time 26 (n) 16 (n) Sinha (RCT) 65% 0.35 [0.16-0.73] hosp. 9/608 26/610 Bajema (PSM) -30% 1.30 [1.01-1.68] hosp. 162/897 124.3/897 Inaba -127% 2.27 [0.60-7.25] hosp. 5/84 8/210 Goodwin 58% 0.42 [0.05-3.23] hosp. 1/80 10/336 Razia 28% 0.72 [0.28-1.81] hosp. 5/29 13/54 SAVALO Gentile (PSM) 26% 0.74 [0.13-4.18] hosp. case control Tau2 = 0.02, I2 = 66.5%, p = 0.54 Early treatment 4% 0.96 [0.86-1.08] 336/19,034 930.3/37,044 4% lower risk Wan 1% 0.99 [0.93-1.05] hosp. 2,298/6,153 2,541/17,283 Improvement, RR [CI] Treatment Control Tau2 = 0.00, I2 = 0.0%, p = 0.7 Late treatment 1% 0.99 [0.93-1.05] 2,298/6,153 2,541/17,283 1% lower risk All studies 2% 0.98 [0.90-1.07] 2,634/25,187 3,471.3/54,327 2% lower risk 20 molnupiravir COVID-19 hospitalization results c19 earlyOctober 2024 Tau2 = 0.01, I2 = 64.7%, p = 0.68 Favors molnupiravir Favors control
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2+ Fischer (RCT) 77% 0.23 [0.01-5.69] death 0/140 1/62 Improvement, RR [CI] Treatment Control Hetero (RCT) 70% 0.30 [0.13-0.70] hosp. 7/371 23/370 MOVe-OUT Jayk Ber.. (DB RCT) 89% 0.11 [0.01-0.86] death 1/709 9/699 Tippabhotla (RCT) 46% 0.54 [0.22-1.34] hosp. 7/610 13/610 Wong (PSM) 52% 0.48 [0.40-0.59] death 1,856 (n) 1,856 (n) Yip (PSW) -12% 1.12 [0.68-1.82] death/ICU Flisiak 39% 0.61 [0.38-0.97] death 20/203 63/387 AGILE CST-2 Khoo (DB RCT) 67% 0.33 [0.01-8.08] oxygen 0/90 1/90 Kneidinger -15% 1.15 [0.56-2.37] severe case 8/46 26/172 Najjar-Deb.. (PSM) 19% 0.81 [0.46-1.43] death 22/2,661 27/2,661 Arbel 65+ 74% 0.26 [0.10-0.73] death 4/845 137/12,724 Arbel 40-64 -1182% 12.82 [3.41-48.2] death 4/224 7/6,075 Suzuki (PSM) -100% 2.00 [0.34-11.9] death 2/230 3/690 Brown -101% 2.01 [0.43-9.38] hosp. 8/442 2/222 PANORAMIC Butler (RCT) -27% 1.27 [0.65-2.48] death 20/11,778 15/11,230 Wong (PSM) 24% 0.76 [0.61-0.95] death Liu -162% 2.62 [0.11-60.6] ICU 1/26 0/16 Sinha (RCT) 65% 0.35 [0.16-0.73] hosp. 9/608 26/610 Zheng -100% 2.00 [1.23-3.23] death/hosp. 61/2,689 34/3,331 OT1 Bajema (PSM) 18% 0.82 [0.52-1.29] death 24/897 29.0/897 Inaba 58% 0.42 [0.02-10.1] death 0/84 1/210 Zheng (PSW) -285% 3.85 [1.54-10.0] death/hosp. 11/802 33/4,836 OT1 Evans 51% 0.49 [0.29-0.83] death/hosp. 359 (n) 4,973 (n) Goodwin -110% 2.10 [0.19-22.9] death 1/80 2/336 Tazare -9% 1.09 [0.93-1.27] death/hosp. Butt -9% 1.09 [0.73-1.63] death/hosp. 48/1,459 44/1,459 Fung 4% 0.96 [0.93-0.99] PASC population-based cohort LONG COVID Cheng 15% 0.85 [0.77-0.95] death 4,146 (n) 5,792 (n) Razia -272% 3.72 [0.35-39.4] death 2/29 1/54 Yen 18% 0.82 [0.50-1.33] death 250 (n) 1,946 (n) SAVALO Gentile (PSM) 4% 0.96 [0.70-1.31] death case control Tau2 = 0.07, I2 = 80.0%, p = 0.12 Early treatment 11% 0.89 [0.77-1.03] 260/31,634 497.0/62,308 11% lower risk MOVe-IN Arribas (DB RCT) -282% 3.82 [0.50-29.1] death 11/216 1/75 Improvement, RR [CI] Treatment Control Wan 11% 0.89 [0.81-0.98] death 704/6,153 2,541/17,283 Wan 13% 0.87 [0.81-0.93] death 2,700 (n) 13,795 (n) Özdemir -50% 1.50 [0.27-8.49] death 3/39 2/39 RECOVERY Horby (RCT) -11% 1.11 [0.79-1.58] death 57/445 55/478 Lv -53% 1.53 [0.83-2.83] death 12/67 30/257 Lai 10% 0.90 [0.83-0.97] death 4,975 (n) 8,667 (n) Tau2 = 0.00, I2 = 18.8%, p < 0.0001 Late treatment 11% 0.89 [0.85-0.95] 787/14,595 2,629/40,594 11% lower risk All studies 10% 0.90 [0.83-0.99] 1,047/46,229 3,126.0/102,902 10% lower risk 38 molnupiravir COVID-19 serious outcomes c19 earlyOctober 2024 Tau2 = 0.03, I2 = 77.3%, p = 0.03 Effect extraction pre-specified (most serious outcome) 1 OT: comparison with other treatment Favors molnupiravir Favors control
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2+ Hetero (RCT) 33% 0.67 [0.54-0.82] recov. time 371 (n) 370 (n) Improvement, RR [CI] Treatment Control Khoo (RCT) -33% 1.33 [0.55-3.26] no recov. 8/12 3/6 MOVe-OUT Jayk Ber.. (DB RCT) 15% 0.85 [0.75-0.98] recovery 709 (n) 699 (n) Zou (RCT) 29% 0.71 [0.28-1.85] recov. time 77 (n) 31 (n) AGILE CST-2 Khoo (DB RCT) -12% 1.12 [0.71-1.79] no recov. 27/90 24/90 PANORAMIC Butler (RCT) 22% 0.78 [0.75-0.81] no recov. 3,856/12,403 4,838/12,140 DAWN Tare (RCT) -83% 1.83 [0.69-4.82] no recov. 4/7 5/16 Tau2 = 0.01, I2 = 44.4%, p = 0.00027 Early treatment 19% 0.81 [0.72-0.91] 3,895/13,669 4,870/13,352 19% lower risk 033864 (RCT) 0% 1.00 [0.50-2.00] improv. n/a n/a FUTILITY, PENDING1 Improvement, RR [CI] Treatment Control 035424 (RCT) 0% 1.00 [0.50-2.00] improv. n/a n/a FUTILITY, PENDING1 MOVe-IN Arribas (DB RCT) 1% 0.99 [0.68-1.45] no recov. 72 (n) 75 (n) RECOVERY Horby (RCT) -9% 1.09 [0.88-1.35] no disch. 126/445 124/478 Tau2 = 0.00, I2 = 0.0%, p = 0.53 Late treatment -6% 1.06 [0.89-1.26] 126/517 124/553 6% higher risk All studies 12% 0.88 [0.78-0.99] 4,021/14,186 4,994/13,905 12% lower risk 11 molnupiravir COVID-19 recovery results c19 earlyOctober 2024 Tau2 = 0.01, I2 = 55.0%, p = 0.031 1 FUTILITY: terminated for futility, results pending Favors molnupiravir Favors control
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1.75
2+ MOVe-AHEAD Alpizar (DB RCT) 24% 0.76 [0.57-1.01] symp. case 78/763 103/764 Improvement, RR [CI] Treatment Control Tau2 = 0.00, I2 = 0.0%, p = 0.049 Prophylaxis 24% 0.76 [0.57-1.01] 78/763 103/764 24% lower risk All studies 24% 0.76 [0.57-1.01] 78/763 103/764 24% lower risk 1 molnupiravir COVID-19 case result c19 earlyOctober 2024 Tau2 = 0.00, I2 = 0.0%, p = 0.049 Favors molnupiravir Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+ Fischer (RCT) 49% 0.51 [0.22-1.18] viral+ 10/118 9/54 Improvement, RR [CI] Treatment Control Optimus (RCT) 58% 0.42 [0.31-0.58] viral+ 38/175 93/180 MOVe-OUT Jayk Ber.. (DB RCT) 4% 0.96 [0.90-1.02] viral load 518 (n) 510 (n) Tippabhotla (RCT) 59% 0.41 [0.29-0.57] viral+ 42/610 103/610 Wong (PSM) 28% 0.72 [0.61-0.87] viral+ 1,856 (n) 1,856 (n) Zou (RCT) 10% 0.90 [0.83-0.97] viral time 76 (n) 31 (n) AGILE CST-2 Khoo (DB RCT) 23% 0.77 [0.58-1.09] viral+ 90 (n) 90 (n) PANORAMIC Butler (RCT) -95% 1.95 [1.15-3.31] viral load 21 (n) 11 (n) Liu 21% 0.79 [0.59-1.05] viral time 26 (n) 16 (n) Sinha (RCT) 48% 0.52 [0.42-0.63] viral load 608 (n) 610 (n) Standing (RCT) -103% 2.03 [0.52-7.94] viral+ 6/117 3/119 Tau2 = 0.06, I2 = 89.2%, p = 0.0006 Early treatment 27% 0.73 [0.60-0.87] 96/4,215 208/4,087 27% lower risk MOVe-IN Arribas (DB RCT) 12% 0.88 [0.62-1.25] viral+ 26/52 34/60 Improvement, RR [CI] Treatment Control RECOVERY Horby (RCT) 12% 0.88 [0.85-0.91] viral load 445 (n) 478 (n) Tau2 = 0.00, I2 = 0.0%, p < 0.0001 Late treatment 12% 0.88 [0.85-0.91] 26/497 34/538 12% lower risk All studies 25% 0.75 [0.67-0.85] 122/4,712 242/4,625 25% lower risk 13 molnupiravir COVID-19 viral clearance results c19 earlyOctober 2024 Tau2 = 0.03, I2 = 87.1%, p < 0.0001 Favors molnupiravir Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+ Fischer (RCT) 77% 0.23 [0.01-5.69] death 0/140 1/62 Improvement, RR [CI] Treatment Control Hetero (RCT) 70% 0.30 [0.13-0.70] hosp. 7/371 23/370 Optimus (RCT) 58% 0.42 [0.31-0.58] viral+ 38/175 93/180 Khoo (RCT) -33% 1.33 [0.55-3.26] no recov. 8/12 3/6 MOVe-OUT Jayk Ber.. (DB RCT) 89% 0.11 [0.01-0.86] death 1/709 9/699 Tippabhotla (RCT) 46% 0.54 [0.22-1.34] hosp. 7/610 13/610 Zou (RCT) 29% 0.71 [0.28-1.85] recov. time 77 (n) 31 (n) AGILE CST-2 Khoo (DB RCT) 67% 0.33 [0.01-8.08] oxygen 0/90 1/90 PANORAMIC Butler (RCT) -27% 1.27 [0.65-2.48] death 20/11,778 15/11,230 Sinha (RCT) 65% 0.35 [0.16-0.73] hosp. 9/608 26/610 DAWN Tare (RCT) -83% 1.83 [0.69-4.82] no recov. 4/7 5/16 Standing (RCT) -103% 2.03 [0.52-7.94] viral+ 6/117 3/119 Tau2 = 0.29, I2 = 61.3%, p = 0.052 Early treatment 35% 0.65 [0.42-1.00] 100/14,694 192/14,023 35% lower risk 033864 (RCT) 0% 1.00 [0.50-2.00] improv. n/a n/a FUTILITY, PENDING1 Improvement, RR [CI] Treatment Control 035424 (RCT) 0% 1.00 [0.50-2.00] improv. n/a n/a FUTILITY, PENDING1 MOVe-IN Arribas (DB RCT) -282% 3.82 [0.50-29.1] death 11/216 1/75 RECOVERY Horby (RCT) -11% 1.11 [0.79-1.58] death 57/445 55/478 Tau2 = 0.00, I2 = 0.0%, p = 0.51 Late treatment -10% 1.10 [0.83-1.46] 68/661 56/553 10% higher risk MOVe-AHEAD Alpizar (DB RCT) 24% 0.76 [0.57-1.01] symp. case 78/763 103/764 Improvement, RR [CI] Treatment Control Tau2 = 0.00, I2 = 0.0%, p = 0.049 Prophylaxis 24% 0.76 [0.57-1.01] 78/763 103/764 24% lower risk All studies 23% 0.77 [0.57-1.04] 246/16,118 351/15,340 23% lower risk 17 molnupiravir COVID-19 Randomized Controlled Trials c19 earlyOctober 2024 Tau2 = 0.19, I2 = 63.7%, p = 0.087 Effect extraction pre-specified 1 FUTILITY: terminated for futility, results pending Favors molnupiravir Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+ Fischer (RCT) 77% 0.23 [0.01-5.69] 0/140 1/62 Improvement, RR [CI] Treatment Control MOVe-OUT Jayk Ber.. (DB RCT) 89% 0.11 [0.01-0.86] 1/709 9/699 PANORAMIC Butler (RCT) -27% 1.27 [0.65-2.48] 20/11,778 15/11,230 Tau2 = 1.60, I2 = 64.8%, p = 0.36 Early treatment 58% 0.42 [0.07-2.56] 21/12,627 25/11,991 58% lower risk MOVe-IN Arribas (DB RCT) -282% 3.82 [0.50-29.1] 11/216 1/75 Improvement, RR [CI] Treatment Control RECOVERY Horby (RCT) -11% 1.11 [0.79-1.58] 57/445 55/478 Tau2 = 0.21, I2 = 27.3%, p = 0.51 Late treatment -35% 1.35 [0.56-3.26] 68/661 56/553 35% higher risk All studies -1% 1.01 [0.54-1.91] 89/13,288 81/12,544 1% higher risk 5 molnupiravir COVID-19 RCT mortality results c19 earlyOctober 2024 Tau2 = 0.19, I2 = 45.4%, p = 0.98 Favors molnupiravir Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+ Hetero (RCT) 70% 0.30 [0.13-0.70] hosp. 7/371 23/370 Improvement, RR [CI] Treatment Control Khoo (RCT) -33% 1.33 [0.55-3.26] no recov. 8/12 3/6 MOVe-OUT Jayk Ber.. (DB RCT) 89% 0.11 [0.01-0.86] death 1/709 9/699 Tippabhotla (RCT) 46% 0.54 [0.22-1.34] hosp. 7/610 13/610 Wong (PSM) 52% 0.48 [0.40-0.59] death 1,856 (n) 1,856 (n) Yip (PSW) -12% 1.12 [0.68-1.82] death/ICU Zou (RCT) 29% 0.71 [0.28-1.85] recov. time 77 (n) 31 (n) Flisiak 39% 0.61 [0.38-0.97] death 20/203 63/387 AGILE CST-2 Khoo (DB RCT) 67% 0.33 [0.01-8.08] oxygen 0/90 1/90 Kneidinger -15% 1.15 [0.56-2.37] severe case 8/46 26/172 Najjar-Deb.. (PSM) 19% 0.81 [0.46-1.43] death 22/2,661 27/2,661 Suzuki (PSM) -100% 2.00 [0.34-11.9] death 2/230 3/690 Brown -101% 2.01 [0.43-9.38] hosp. 8/442 2/222 PANORAMIC Butler (RCT) -27% 1.27 [0.65-2.48] death 20/11,778 15/11,230 Wong (PSM) 24% 0.76 [0.61-0.95] death Liu -162% 2.62 [0.11-60.6] ICU 1/26 0/16 Sinha (RCT) 65% 0.35 [0.16-0.73] hosp. 9/608 26/610 Zheng -100% 2.00 [1.23-3.23] death/hosp. 61/2,689 34/3,331 OT1 Evans 51% 0.49 [0.29-0.83] death/hosp. 359 (n) 4,973 (n) Goodwin -110% 2.10 [0.19-22.9] death 1/80 2/336 Butt -9% 1.09 [0.73-1.63] death/hosp. 48/1,459 44/1,459 Fung 4% 0.96 [0.93-0.99] PASC population-based cohort LONG COVID DAWN Tare (RCT) -83% 1.83 [0.69-4.82] no recov. 4/7 5/16 Cheng 15% 0.85 [0.77-0.95] death 4,146 (n) 5,792 (n) Standing (RCT) -103% 2.03 [0.52-7.94] viral+ 6/117 3/119 Razia -272% 3.72 [0.35-39.4] death 2/29 1/54 Yen 18% 0.82 [0.50-1.33] death 250 (n) 1,946 (n) Tau2 = 0.06, I2 = 76.1%, p = 0.032 Early treatment 15% 0.85 [0.73-0.99] 235/28,855 300/37,676 15% lower risk MOVe-IN Arribas (DB RCT) -282% 3.82 [0.50-29.1] death 11/216 1/75 Improvement, RR [CI] Treatment Control Wan 11% 0.89 [0.81-0.98] death 704/6,153 2,541/17,283 Wan 13% 0.87 [0.81-0.93] death 2,700 (n) 13,795 (n) Özdemir -50% 1.50 [0.27-8.49] death 3/39 2/39 Lv -53% 1.53 [0.83-2.83] death 12/67 30/257 Lai 10% 0.90 [0.83-0.97] death 4,975 (n) 8,667 (n) Tau2 = 0.00, I2 = 13.3%, p < 0.0001 Late treatment 11% 0.89 [0.84-0.93] 730/14,150 2,574/40,116 11% lower risk MOVe-AHEAD Alpizar (DB RCT) 24% 0.76 [0.57-1.01] symp. case 78/763 103/764 Improvement, RR [CI] Treatment Control Tau2 = 0.00, I2 = 0.0%, p = 0.049 Prophylaxis 24% 0.76 [0.57-1.01] 78/763 103/764 24% lower risk All studies 14% 0.86 [0.79-0.94] 1,043/43,768 2,977/78,556 14% lower risk 34 molnupiravir COVID-19 peer reviewed studies c19 earlyOctober 2024 Tau2 = 0.02, I2 = 73.0%, p = 0.00089 Effect extraction pre-specified (most serious outcome) 1 OT: comparison with other treatment Favors molnupiravir Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+ Fischer (RCT) 77% 0.23 [0.01-5.69] death 0/140 1/62 Improvement, RR [CI] Treatment Control Fischer (RCT) 65% 0.35 [0.01-8.33] death 0/55 1/62 Fischer (RCT) 67% 0.33 [0.01-8.03] death 0/62 1/62 Fischer (RCT) 58% 0.42 [0.02-10.0] death 0/23 1/62 Fischer (RCT) -33% 1.33 [0.14-12.5] hosp. 3/140 1/62 Fischer (RCT) -13% 1.13 [0.07-17.6] hosp. 1/55 1/62 Fischer (RCT) -100% 2.00 [0.19-21.5] hosp. 2/62 1/62 Fischer (RCT) 58% 0.42 [0.02-10.0] hosp. 0/23 1/62 Fischer (RCT) 49% 0.51 [0.22-1.18] viral+ 10/118 9/54 Fischer (RCT) 89% 0.11 [0.01-0.86] viral+ 1/53 9/54 Fischer (RCT) 30% 0.70 [0.25-1.93] viral+ 5/43 9/54 Fischer (RCT) -9% 1.09 [0.37-3.18] viral+ 4/22 9/54 Fischer (RCT) 92% 0.08 [0.01-0.62] viral+ 1/117 6/54 Fischer (RCT) 92% 0.08 [0.01-0.75] viral+ 0/53 6/54 Fischer (RCT) 91% 0.09 [0.01-0.83] viral+ 0/42 6/54 Fischer (RCT) 59% 0.41 [0.05-3.20] viral+ 1/22 6/54 Fischer (RCT) 30% 0.70 [0.37-1.36] viral+ 19/137 12/61 Fischer (RCT) 62% 0.38 [0.13-1.12] viral+ 4/53 12/61 Fischer (RCT) -8% 1.08 [0.54-2.18] viral+ 13/61 12/61 Fischer (RCT) 56% 0.44 [0.11-1.83] viral+ 2/23 12/61 Hetero (RCT) 70% 0.30 [0.13-0.70] hosp. 7/371 23/370 Hetero (RCT) 33% 0.67 [0.54-0.82] recov. time 371 (n) 370 (n) Optimus (RCT) 58% 0.42 [0.31-0.58] viral+ 38/175 93/180 Khoo (RCT) -33% 1.33 [0.55-3.26] no recov. 8/12 3/6 Khoo (RCT) -100% 2.00 [0.28-14.2] no recov. 4/12 1/6 Khoo (RCT) -100% 2.00 [0.90-4.43] no recov. 4/4 3/6 Khoo (RCT) 0% 1.00 [0.28-3.54] no recov. 2/4 3/6 Khoo (RCT) 0% 1.00 [0.28-3.54] no recov. 2/4 3/6 Khoo (RCT) -50% 1.50 [0.13-17.7] no recov. 1/4 1/6 Khoo (RCT) -200% 3.00 [0.39-23.1] no recov. 2/4 1/6 Khoo (RCT) -50% 1.50 [0.13-17.7] no recov. 1/4 1/6 MOVe-OUT Jayk Ber.. (DB RCT) 89% 0.11 [0.01-0.86] death 1/709 9/699 MOVe-OUT Jayk Ber.. (DB RCT) 30% 0.70 [0.48-1.00] death/hosp. 48/709 68/699 MOVe-OUT Jayk Ber.. (DB RCT) 94% 0.06 [0.00-0.97] death/hosp. 0/37 9/47 MOVe-OUT Jayk Ber.. (DB RCT) 50% 0.50 [0.20-1.26] death/hosp. 6/75 13/82 MOVe-OUT Jayk Ber.. (DB RCT) 24% 0.76 [0.42-1.38] death/hosp. 18/237 22/221 MOVe-OUT Jayk Ber.. (DB RCT) 42% 0.58 [0.20-1.68] death/hosp. 5/47 7/38 MOVe-OUT Jayk Ber.. (DB RCT) 15% 0.85 [0.75-0.98] recovery 709 (n) 699 (n) MOVe-OUT Jayk Ber.. (DB RCT) 19% 0.81 [0.71-0.92] recovery 709 (n) 699 (n) MOVe-OUT Jayk Ber.. (DB RCT) 15% 0.85 [0.75-0.97] recovery 709 (n) 699 (n) MOVe-OUT Jayk Ber.. (DB RCT) 14% 0.86 [0.76-0.97] recovery 709 (n) 699 (n) MOVe-OUT Jayk Ber.. (DB RCT) 4% 0.96 [0.90-1.02] viral load 518 (n) 510 (n) MOVe-OUT Jayk Ber.. (DB RCT) -2% 1.02 [0.97-1.08] viral load 516 (n) 513 (n) MOVe-OUT Jayk Ber.. (DB RCT) 1% 0.99 [0.93-1.05] viral load 515 (n) 506 (n) MOVe-OUT Jayk Ber.. (DB RCT) 13% 0.87 [0.79-0.95] viral load 558 (n) 547 (n) MOVe-OUT Jayk Ber.. (DB RCT) 17% 0.83 [0.71-0.97] viral load 570 (n) 570 (n) Tippabhotla (RCT) 46% 0.54 [0.22-1.34] hosp. 7/610 13/610 Tippabhotla (RCT) 46% 0.54 [0.41-0.71] no improv. 67/610 125/610 Tippabhotla (RCT) 52% 0.48 [0.42-0.54] no improv. 199/610 417/610 Tippabhotla (RCT) 25% 0.75 [0.71-0.79] no improv. 433/610 576/610 Tippabhotla (RCT) 59% 0.41 [0.29-0.57] viral+ 42/610 103/610 Tippabhotla (RCT) 81% 0.19 [0.15-0.24] viral+ 62/610 327/610 Tippabhotla (RCT) 78% 0.22 [0.19-0.27] viral+ 113/610 505/610 Wong (PSM) 52% 0.48 [0.40-0.59] death 1,856 (n) 1,856 (n) Wong (PSM) 58% 0.42 [0.17-1.01] ventilation 1,856 (n) 1,856 (n) Wong (PSM) 40% 0.60 [0.52-0.69] progression 1,856 (n) 1,856 (n) Wong (PSM) 6% 0.94 [0.89-1.00] hosp. time 1,856 (n) 1,856 (n) Wong (PSM) 28% 0.72 [0.61-0.87] viral+ 1,856 (n) 1,856 (n) Yip (PSW) -12% 1.12 [0.68-1.82] death/ICU Yip (PSW) -17% 1.17 [0.99-1.39] hosp. Zou (RCT) 29% 0.71 [0.28-1.85] recov. time 77 (n) 31 (n) Zou (RCT) 10% 0.90 [0.83-0.97] viral time 76 (n) 31 (n) Zou (RCT) 51% 0.49 [0.28-0.84] viral+ 18/76 15/31 Zou (RCT) 37% 0.63 [0.51-0.78] viral+ 45/76 29/31 Zou (RCT) 18% 0.82 [0.73-0.92] viral+ 62/76 31/31 Flisiak 39% 0.61 [0.38-0.97] death 20/203 63/387 Flisiak 5% 0.95 [0.39-2.32] ventilation 7/203 14/387 Flisiak -1% 1.01 [0.71-1.43] hosp. time 203 (n) 387 (n) AGILE CST-2 Khoo (DB RCT) 67% 0.33 [0.01-8.08] oxygen 0/90 1/90 AGILE CST-2 Khoo (DB RCT) 89% 0.11 [0.01-2.03] hosp. 0/90 4/90 AGILE CST-2 Khoo (DB RCT) -12% 1.12 [0.71-1.79] no recov. 27/90 24/90 AGILE CST-2 Khoo (DB RCT) 23% 0.77 [0.58-1.09] viral+ 90 (n) 90 (n) Kneidinger -15% 1.15 [0.56-2.37] severe case 8/46 26/172 Najjar-Deb.. (PSM) 19% 0.81 [0.46-1.43] death 22/2,661 27/2,661 Najjar-Deb.. (PSM) 17% 0.83 [0.57-1.21] progression 50/2,661 60/2,661 Najjar-Deb.. (PSM) 25% 0.75 [0.51-1.12] severe case 43/2,661 57/2,661 Arbel 65+ 74% 0.26 [0.10-0.73] death 4/845 137/12,724 Arbel 65+ -1182% 12.82 [3.41-48.2] death 4/224 7/6,075 Arbel 65+ 45% 0.55 [0.34-0.88] hosp. 18/845 513/12,724 Arbel 65+ -80% 1.80 [0.86-3.77] hosp. 8/224 97/6,075 Arbel 40-64 -1182% 12.82 [3.41-48.2] death 4/224 7/6,075 Arbel 40-64 -80% 1.80 [0.86-3.77] hosp. 8/224 97/6,075 Suzuki (PSM) -100% 2.00 [0.34-11.9] death 2/230 3/690 Suzuki (PSM) 57% 0.43 [0.02-10.5] ventilation 0/230 1/690 Suzuki (PSM) 53% 0.47 [0.22-0.98] progression 9/230 58/690 Brown -101% 2.01 [0.43-9.38] hosp. 8/442 2/222 PANORAMIC Butler (RCT) -27% 1.27 [0.65-2.48] death 20/11,778 15/11,230 PANORAMIC Butler (RCT) 40% 0.60 [0.14-2.51] death 3/12,529 5/12,525 PANORAMIC Butler (RCT) -6% 1.06 [0.81-1.41] death/hosp. 105/12,529 98/12,525 PANORAMIC Butler (RCT) -7% 1.07 [0.81-1.41] hosp. 103/12,529 96/12,525 PANORAMIC Butler (RCT) 2% 0.98 [0.94-1.01] transmission 3,887/10,803 3,873/10,548 PANORAMIC Butler (RCT) 22% 0.78 [0.75-0.81] no recov. 3,856/12,403 4,838/12,140 PANORAMIC Butler (RCT) 19% 0.81 [0.78-0.83] recov. time 12,403 (n) 12,140 (n) PANORAMIC Butler (RCT) 30% 0.70 [0.67-0.73] no recov. 2,675/12,403 3,766/12,140 PANORAMIC Butler (RCT) 26% 0.74 [0.71-0.76] recov. time 12,403 (n) 12,140 (n) PANORAMIC Butler (RCT) -95% 1.95 [1.15-3.31] viral load 21 (n) 11 (n) PANORAMIC Butler (RCT) 92% 0.08 [0.05-0.14] viral load 33 (n) 26 (n) Wong (PSM) 24% 0.76 [0.61-0.95] death Wong (PSM) 60% 0.40 [0.19-0.84] ventilation Wong (PSM) 26% 0.74 [0.45-1.21] ICU Wong (PSM) 2% 0.98 [0.89-1.06] hosp. Liu -162% 2.62 [0.11-60.6] ICU 1/26 0/16 Liu 8% 0.92 [0.17-4.94] progression 3/26 2/16 Liu 18% 0.82 [0.63-1.06] hosp. time 26 (n) 16 (n) Liu 21% 0.79 [0.59-1.05] viral time 26 (n) 16 (n) Liu -23% 1.23 [0.12-12.5] viral+ 2/26 1/16 Liu 28% 0.72 [0.29-1.76] viral+ 7/26 6/16 Liu 38% 0.62 [0.41-0.92] viral+ 14/26 14/16 Liu 18% 0.82 [0.64-1.05] viral+ 20/26 15/16 Liu 12% 0.88 [0.75-1.05] viral+ 23/26 16/16 Sinha (RCT) 65% 0.35 [0.16-0.73] hosp. 9/608 26/610 Sinha (RCT) 53% 0.47 [0.26-0.85] no improv. 16/608 34/610 Sinha (RCT) 48% 0.52 [0.42-0.63] viral load 608 (n) 610 (n) Zheng -100% 2.00 [1.23-3.23] death/hosp. 61/2,689 34/3,331 OT1 Zheng -85% 1.85 [1.14-3.03] death/hosp. 55/2,689 32/3,331 OT1 Bajema (PSM) 18% 0.82 [0.52-1.29] death 24/897 29.0/897 Bajema (PSM) 49% 0.51 [0.20-1.27] death 7/897 13.8/897 Bajema (PSM) 17% 0.83 [0.17-4.12] ventilation 3/897 3.6/897 Bajema (PSM) 1% 0.99 [0.41-2.37] ICU 10/897 10.1/897 Bajema (PSM) -30% 1.30 [1.01-1.68] hosp. 162/897 124.3/897 Bajema (PSM) 9% 0.91 [0.59-1.41] hosp. 37/897 40.5/897 Inaba 58% 0.42 [0.02-10.1] death 0/84 1/210 Inaba -127% 2.27 [0.60-7.25] death/hosp. 5/84 8/210 Inaba -127% 2.27 [0.60-7.25] hosp. 5/84 8/210 Zheng (PSW) -285% 3.85 [1.54-10.0] death/hosp. 11/802 33/4,836 OT1 Evans 51% 0.49 [0.29-0.83] death/hosp. 359 (n) 4,973 (n) Goodwin -110% 2.10 [0.19-22.9] death 1/80 2/336 Goodwin 58% 0.42 [0.05-3.23] hosp. 1/80 10/336 Goodwin 53% 0.47 [0.11-1.97] hosp. 2/80 18/336 Tazare -9% 1.09 [0.93-1.27] death/hosp. Butt -9% 1.09 [0.73-1.63] death/hosp. 48/1,459 44/1,459 Fung 4% 0.96 [0.93-0.99] PASC population-based cohort LONG COVID Fung 8% 0.92 [0.90-0.94] PASC population-based cohort LONG COVID DAWN Tare (RCT) -83% 1.83 [0.69-4.82] no recov. 4/7 5/16 DAWN Tare (RCT) 0% 1.00 [0.61-1.63] no recov. 6/8 12/16 Cheng 15% 0.85 [0.77-0.95] death 4,146 (n) 5,792 (n) Cheng -0% 1.00 [0.76-1.33] oxygen 4,146 (n) 5,792 (n) Cheng 12% 0.88 [0.59-1.30] ICU 4,146 (n) 5,792 (n) Standing (RCT) -103% 2.03 [0.52-7.94] viral+ 6/117 3/119 Standing (RCT) 31% 0.69 [0.44-1.07] viral+ 26/249 52/343 Razia -272% 3.72 [0.35-39.4] death 2/29 1/54 Razia -86% 1.86 [0.12-28.7] ventilation 1/29 1/54 Razia -86% 1.86 [0.28-12.5] ICU 2/29 2/54 Razia 28% 0.72 [0.28-1.81] hosp. 5/29 13/54 Yen 18% 0.82 [0.50-1.33] death 250 (n) 1,946 (n) SAVALO Gentile (PSM) 4% 0.96 [0.70-1.31] death case control SAVALO Gentile (PSM) 26% 0.74 [0.13-4.18] hosp. case control SAVALO Gentile (PSM) 65% 0.35 [0.15-0.81] progression case control 033864 (RCT) 0% 1.00 [0.50-2.00] improv. n/a n/a FUTILITY, PENDING2 035424 (RCT) 0% 1.00 [0.50-2.00] improv. n/a n/a FUTILITY, PENDING2 MOVe-IN Arribas (DB RCT) -282% 3.82 [0.50-29.1] death 11/216 1/75 MOVe-IN Arribas (DB RCT) -217% 3.17 [0.34-29.8] death 3/71 1/75 MOVe-IN Arribas (DB RCT) -317% 4.17 [0.48-36.4] death 4/72 1/75 MOVe-IN Arribas (DB RCT) -311% 4.11 [0.47-35.9] death 4/73 1/75 MOVe-IN Arribas (DB RCT) 1% 0.99 [0.68-1.45] no recov. 72 (n) 75 (n) MOVe-IN Arribas (DB RCT) 12% 0.88 [0.61-1.28] no recov. 73 (n) 75 (n) MOVe-IN Arribas (DB RCT) -1% 1.01 [0.69-1.47] no recov. 73 (n) 75 (n) MOVe-IN Arribas (DB RCT) 12% 0.88 [0.62-1.25] viral+ 26/52 34/60 MOVe-IN Arribas (DB RCT) -2% 1.02 [0.74-1.41] viral+ 29/50 34/60 MOVe-IN Arribas (DB RCT) 21% 0.79 [0.56-1.13] viral+ 27/60 34/60 MOVe-IN Arribas (DB RCT) 8% 0.92 [0.41-2.08] viral+ 9/53 10/54 MOVe-IN Arribas (DB RCT) -48% 1.48 [0.72-3.03] viral+ 14/51 10/54 MOVe-IN Arribas (DB RCT) 21% 0.79 [0.34-1.84] viral+ 8/55 10/54 Wan 11% 0.89 [0.81-0.98] death 704/6,153 2,541/17,283 Wan 1% 0.99 [0.93-1.05] hosp. 2,298/6,153 2,541/17,283 Wan -4% 1.04 [0.98-1.10] progression 2,300/6,153 2,541/17,283 Wan 13% 0.87 [0.81-0.93] death 2,700 (n) 13,795 (n) Wan -7% 1.07 [0.89-1.30] ventilation 2,700 (n) 13,795 (n) Wan -2% 1.02 [0.76-1.36] ICU 2,700 (n) 13,795 (n) Özdemir -50% 1.50 [0.27-8.49] death 3/39 2/39 Özdemir 0% 1.00 [0.15-6.75] ICU 2/39 2/39 RECOVERY Horby (RCT) -11% 1.11 [0.79-1.58] death 57/445 55/478 RECOVERY Horby (RCT) 7% 0.93 [0.68-1.28] death 74/445 79/478 RECOVERY Horby (RCT) -43% 1.43 [0.50-4.08] ventilation 8/445 6/476 RECOVERY Horby (RCT) -9% 1.09 [0.88-1.35] no disch. 126/445 124/478 RECOVERY Horby (RCT) 12% 0.88 [0.85-0.91] viral load 445 (n) 478 (n) Lv -53% 1.53 [0.83-2.83] death 12/67 30/257 Lai 10% 0.90 [0.83-0.97] death 4,975 (n) 8,667 (n) MOVe-AHEAD Alpizar (DB RCT) 24% 0.76 [0.57-1.01] symp. case 78/763 103/764 Molnupiravir COVID-19 outcomes c19 earlyOctober 2024 1 OT: comparison with other treatment 2 FUTILITY: terminated for futility, results pending Favors molnupiravir Favors control
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